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Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis.
Cornea. 2022 Apr 01; 41(4):427-434.C

Abstract

PURPOSE

The purpose of this study was to evaluate the efficacy of topical ivermectin 1% cream application on the eyelashes in combination with eyelid hygiene in the treatment of Demodex blepharitis.

METHODS

One hundred two eyes of 102 patients with symptomatic Demodex blepharitis were divided into 2 groups according to the use of topical ivermectin in this retrospective case-control study. The ivermectin group (n = 51) applied topical ivermectin 1% cream on the eyelashes for 15 minutes once weekly, but the control group (n = 51) did not. In both groups, eyelid hygiene was performed once daily. The Standard Patient Evaluation of Eye Dryness (SPEED) symptom questionnaire score, Oxford staining score, eyelid debris, eyelid redness/swelling, and telangiectasia were assessed during the follow-up visits.

RESULTS

The mean follow-up periods of the ivermectin and control groups were 15.1 ± 9.7 weeks and 14.8 ± 8.6 weeks, respectively. The SPEED score and eyelid debris grade were significantly improved in both groups during the follow-up, although the SPEED score and eyelid debris grade showed greater changes in the ivermectin group than in the control group. The Oxford staining score, eyelid redness/swelling grade, and telangiectasia grade were significantly improved only in the ivermectin group but not in the control group.

CONCLUSIONS

In patients with Demodex blepharitis, the use of topical ivermectin 1% cream for 15 minutes once weekly in addition to eyelid hygiene had more significantly improved symptoms, ocular surface staining, eyelid debris, redness/swelling, and telangiectasia as compared with eyelid hygiene alone. These findings support the efficacy of topical ivermectin 1% cream application in the treatment of Demodex blepharitis.

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Authors+Show Affiliations

Choi Y
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea. Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Eom Y
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea. Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Yoon EG
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea. Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Song JS
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea. Department of Ophthalmology, Korea University Guro Hospital, Seoul, Republic of Korea.
Kim IH
Department of Dermatology, Korea University College of Medicine, Seoul, Republic of Korea; and. Department of Dermatology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Kim HM
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.

MeSH

Administration, OphthalmicAdultAgedAged, 80 and overAntiparasitic AgentsBlepharitisCase-Control StudiesEye Infections, ParasiticEyelashesFemaleFollow-Up StudiesHumansIvermectinMaleMiddle AgedMite InfestationsRetrospective StudiesSkin CreamSurveys and QuestionnairesTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34173370

Clinical Trial Links

Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1%

Citation

Choi, Young, et al. "Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis." Cornea, vol. 41, no. 4, 2022, pp. 427-434.
Choi Y, Eom Y, Yoon EG, et al. Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis. Cornea. 2022;41(4):427-434.
Choi, Y., Eom, Y., Yoon, E. G., Song, J. S., Kim, I. H., & Kim, H. M. (2022). Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis. Cornea, 41(4), 427-434. https://doi.org/10.1097/ICO.0000000000002802
Choi Y, et al. Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis. Cornea. 2022 Apr 1;41(4):427-434. PubMed PMID: 34173370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis. AU - Choi,Young, AU - Eom,Youngsub, AU - Yoon,Eun Gyu, AU - Song,Jong Suk, AU - Kim,Il-Hwan, AU - Kim,Hyo Myung, PY - 2021/01/22/received PY - 2021/04/28/accepted PY - 2021/6/27/pubmed PY - 2022/3/12/medline PY - 2021/6/26/entrez SP - 427 EP - 434 JF - Cornea JO - Cornea VL - 41 IS - 4 N2 - PURPOSE: The purpose of this study was to evaluate the efficacy of topical ivermectin 1% cream application on the eyelashes in combination with eyelid hygiene in the treatment of Demodex blepharitis. METHODS: One hundred two eyes of 102 patients with symptomatic Demodex blepharitis were divided into 2 groups according to the use of topical ivermectin in this retrospective case-control study. The ivermectin group (n = 51) applied topical ivermectin 1% cream on the eyelashes for 15 minutes once weekly, but the control group (n = 51) did not. In both groups, eyelid hygiene was performed once daily. The Standard Patient Evaluation of Eye Dryness (SPEED) symptom questionnaire score, Oxford staining score, eyelid debris, eyelid redness/swelling, and telangiectasia were assessed during the follow-up visits. RESULTS: The mean follow-up periods of the ivermectin and control groups were 15.1 ± 9.7 weeks and 14.8 ± 8.6 weeks, respectively. The SPEED score and eyelid debris grade were significantly improved in both groups during the follow-up, although the SPEED score and eyelid debris grade showed greater changes in the ivermectin group than in the control group. The Oxford staining score, eyelid redness/swelling grade, and telangiectasia grade were significantly improved only in the ivermectin group but not in the control group. CONCLUSIONS: In patients with Demodex blepharitis, the use of topical ivermectin 1% cream for 15 minutes once weekly in addition to eyelid hygiene had more significantly improved symptoms, ocular surface staining, eyelid debris, redness/swelling, and telangiectasia as compared with eyelid hygiene alone. These findings support the efficacy of topical ivermectin 1% cream application in the treatment of Demodex blepharitis. SN - 1536-4798 UR - https://brain.unboundmedicine.com/medline/citation/34173370/Efficacy_of_Topical_Ivermectin_1_in_the_Treatment_of_Demodex_Blepharitis_ DB - PRIME DP - Unbound Medicine ER -