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Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea.
Ocul Immunol Inflamm. 2021 Aug 18; 29(6):1137-1141.OI

Abstract

Purpose: To investigate the efficacy of once-daily topical treatment of ocular and cutaneous rosacea with ivermectin 1% cream (Soolantra®, Galderma).Methods: Ten patients with rosacea were evaluated in a retrospective monocentric pilot study. Subjective symptoms (measured with the Ocular Surface Disease Index), skin findings, and ocular changes (blepharitis with telangiectasia and meibomian gland dysfunction, conjunctival redness, tear breakup time (TBUT), and fluorescein staining of the cornea) were evaluated. The follow-up was 8 months (range: 5-12 months).Results: The OSDI score decreased in the 8th week of treatment (38.5 ± 21.7, P = .004). After 16 weeks, blepharitis (P = .004), and conjunctival redness (P = .008) had strongly improved, and grade 1 was seen in all patients until the end of follow-up. Fluorescein staining of the cornea (P = .001) and TBUT (P = .016) showed significant improvement until the last follow-up visit. No side effects were observed. Conclusion: Topical ivermectin cream 1% given daily is an effective and safe therapy against rosacea.

Authors+Show Affiliations

Centre for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.Centre for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.Centre for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.Department of Dermatology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.Centre for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32255398

Citation

Sobolewska, B, et al. "Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea." Ocular Immunology and Inflammation, vol. 29, no. 6, 2021, pp. 1137-1141.
Sobolewska B, Doycheva D, Deuter CM, et al. Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea. Ocul Immunol Inflamm. 2021;29(6):1137-1141.
Sobolewska, B., Doycheva, D., Deuter, C. M., Schaller, M., & Zierhut, M. (2021). Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea. Ocular Immunology and Inflammation, 29(6), 1137-1141. https://doi.org/10.1080/09273948.2020.1727531
Sobolewska B, et al. Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea. Ocul Immunol Inflamm. 2021 Aug 18;29(6):1137-1141. PubMed PMID: 32255398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea. AU - Sobolewska,B, AU - Doycheva,Deshka, AU - Deuter,Christoph M, AU - Schaller,Martin, AU - Zierhut,Manfred, Y1 - 2020/04/07/ PY - 2020/4/8/pubmed PY - 2022/2/26/medline PY - 2020/4/8/entrez KW - Demodex KW - Ivermectin KW - blepharitis KW - dry eye KW - rosacea SP - 1137 EP - 1141 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 29 IS - 6 N2 - Purpose: To investigate the efficacy of once-daily topical treatment of ocular and cutaneous rosacea with ivermectin 1% cream (Soolantra®, Galderma).Methods: Ten patients with rosacea were evaluated in a retrospective monocentric pilot study. Subjective symptoms (measured with the Ocular Surface Disease Index), skin findings, and ocular changes (blepharitis with telangiectasia and meibomian gland dysfunction, conjunctival redness, tear breakup time (TBUT), and fluorescein staining of the cornea) were evaluated. The follow-up was 8 months (range: 5-12 months).Results: The OSDI score decreased in the 8th week of treatment (38.5 ± 21.7, P = .004). After 16 weeks, blepharitis (P = .004), and conjunctival redness (P = .008) had strongly improved, and grade 1 was seen in all patients until the end of follow-up. Fluorescein staining of the cornea (P = .001) and TBUT (P = .016) showed significant improvement until the last follow-up visit. No side effects were observed. Conclusion: Topical ivermectin cream 1% given daily is an effective and safe therapy against rosacea. SN - 1744-5078 UR - https://brain.unboundmedicine.com/medline/citation/32255398/Efficacy_of_Topical_Ivermectin_for_the_Treatment_of_Cutaneous_and_Ocular_Rosacea_ DB - PRIME DP - Unbound Medicine ER -