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Ivermectin: From theory to clinical application.
Int J Antimicrob Agents. 2019 Aug; 54(2):134-142.IJ

Abstract

Approximately 250 million people have been using ivermectin (IVM) annually to combat many parasitic diseases including filariasis, onchocerciasis, strongyloidiasis, scabies and pediculosis. Many clinical studies have proven its efficacy against these diseases and have reported the optimum dose and duration of treatment. Moreover, its antiparasitic range has increased to cover more parasitic infections, but it still requires further exploration, e.g. for trichinosis and myiasis. Furthermore, IVM showed high efficacy in killing vectors of disease-causing parasites such as mosquitoes, sandflies and tsetse flies. The World Health Organization (WHO) has managed many control programmes involving the use of IVM to achieve elimination of onchocerciasis and lymphatic filariasis and to reduce malaria transmission. However, IVM is not exempt from the possibility of resistance and, certainly, its intensive use has led to the emergence of resistance in some parasites. Recent research is investigating the possibility of novel drug delivery systems for IVM that increase its potential to treat a new range of diseases and to overcome the possibility of drug resistance. This review highlights the most common human uses of IVM, with special reference to the new and promising properties of IVM.

Authors+Show Affiliations

Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address: daliaashour1@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31071469

Citation

Ashour, Dalia S.. "Ivermectin: From Theory to Clinical Application." International Journal of Antimicrobial Agents, vol. 54, no. 2, 2019, pp. 134-142.
Ashour DS. Ivermectin: From theory to clinical application. Int J Antimicrob Agents. 2019;54(2):134-142.
Ashour, D. S. (2019). Ivermectin: From theory to clinical application. International Journal of Antimicrobial Agents, 54(2), 134-142. https://doi.org/10.1016/j.ijantimicag.2019.05.003
Ashour DS. Ivermectin: From Theory to Clinical Application. Int J Antimicrob Agents. 2019;54(2):134-142. PubMed PMID: 31071469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ivermectin: From theory to clinical application. A1 - Ashour,Dalia S, Y1 - 2019/05/07/ PY - 2019/01/14/received PY - 2019/04/27/revised PY - 2019/05/01/accepted PY - 2019/5/10/pubmed PY - 2019/12/4/medline PY - 2019/5/10/entrez KW - Filariasis KW - Ivermectin KW - Mass drug administration KW - Mectizan KW - Nanoformulation KW - Onchocerciasis SP - 134 EP - 142 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 54 IS - 2 N2 - Approximately 250 million people have been using ivermectin (IVM) annually to combat many parasitic diseases including filariasis, onchocerciasis, strongyloidiasis, scabies and pediculosis. Many clinical studies have proven its efficacy against these diseases and have reported the optimum dose and duration of treatment. Moreover, its antiparasitic range has increased to cover more parasitic infections, but it still requires further exploration, e.g. for trichinosis and myiasis. Furthermore, IVM showed high efficacy in killing vectors of disease-causing parasites such as mosquitoes, sandflies and tsetse flies. The World Health Organization (WHO) has managed many control programmes involving the use of IVM to achieve elimination of onchocerciasis and lymphatic filariasis and to reduce malaria transmission. However, IVM is not exempt from the possibility of resistance and, certainly, its intensive use has led to the emergence of resistance in some parasites. Recent research is investigating the possibility of novel drug delivery systems for IVM that increase its potential to treat a new range of diseases and to overcome the possibility of drug resistance. This review highlights the most common human uses of IVM, with special reference to the new and promising properties of IVM. SN - 1872-7913 UR - https://brain.unboundmedicine.com/medline/citation/31071469/Ivermectin:_From_theory_to_clinical_application_ DB - PRIME DP - Unbound Medicine ER -