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Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel.
Dermatol Online J. 2015 Sep 17; 21(9)DO

Abstract

Additional evidence that Demodex folliculorum may contribute to the pathogenesis of papulopustular rosacea are new studies of two topical antiparasitic agents. Ivermectin and praziquantel have recently been shown to be effective in decreasing the severity of papulopustular rosacea. These two agents significantly differ in molecular structure, but yield similar antiparasitic mechanisms of action. Higher numbers of Demodex mites are found in the skin of patients with rosacea than in people with normal skin. If Demodex play a role in pathogenesis, then hypersensitivity to the mites, their flora, or their products could explain the observed efficacy of antidemodectic therapy.

Authors+Show Affiliations

Abokwidir M
Wake Forest School of Medicine.
Fleischer AB
No affiliation info available

MeSH

Administration, CutaneousAnimalsAntiparasitic AgentsHumansIvermectinMite InfestationsMitesPraziquantelRosacea

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26437294

Citation

Abokwidir, Manal, and Alan B. Fleischer. "Additional Evidence That Rosacea Pathogenesis May Involve Demodex: New Information From the Topical Efficacy of Ivermectin and Praziquantel." Dermatology Online Journal, vol. 21, no. 9, 2015.
Abokwidir M, Fleischer AB. Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel. Dermatol Online J. 2015;21(9).
Abokwidir, M., & Fleischer, A. B. (2015). Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel. Dermatology Online Journal, 21(9).
Abokwidir M, Fleischer AB. Additional Evidence That Rosacea Pathogenesis May Involve Demodex: New Information From the Topical Efficacy of Ivermectin and Praziquantel. Dermatol Online J. 2015 Sep 17;21(9) PubMed PMID: 26437294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel. AU - Abokwidir,Manal, AU - Fleischer,Alan B,Jr Y1 - 2015/09/17/ PY - 2015/09/17/received PY - 2015/09/17/accepted PY - 2015/10/6/entrez PY - 2015/10/6/pubmed PY - 2016/7/9/medline JF - Dermatology online journal JO - Dermatol Online J VL - 21 IS - 9 N2 - Additional evidence that Demodex folliculorum may contribute to the pathogenesis of papulopustular rosacea are new studies of two topical antiparasitic agents. Ivermectin and praziquantel have recently been shown to be effective in decreasing the severity of papulopustular rosacea. These two agents significantly differ in molecular structure, but yield similar antiparasitic mechanisms of action. Higher numbers of Demodex mites are found in the skin of patients with rosacea than in people with normal skin. If Demodex play a role in pathogenesis, then hypersensitivity to the mites, their flora, or their products could explain the observed efficacy of antidemodectic therapy. SN - 1087-2108 UR - https://brain.unboundmedicine.com/medline/citation/26437294/Additional_evidence_that_rosacea_pathogenesis_may_involve_demodex:_new_information_from_the_topical_efficacy_of_ivermectin_and_praziquantel_ DB - PRIME DP - Unbound Medicine ER -