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Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum.
Int J Infect Dis. 2013 May; 17(5):e343-7.IJ

Abstract

OBJECTIVE

To evaluate the efficacy of ivermectin and combined ivermectin-metronidazole therapy in the treatment of ocular and skin lesions of Demodex folliculorum.

METHODS

One hundred twenty patients with skin lesions and anterior blepharitis, whose infestation was treatment-resistant and who had a Demodex count >5 mites/cm² for skin lesions or ≥ 3 mites at the root of each eyelash, were recruited. The treatment regimens were ivermectin and ivermectin-metronidazole combined therapy. We enrolled 15 patients from each of four groups for each treatment regimen. Demodex was detected by standardized skin surface biopsy for skin lesions. Three eyelashes from each affected lower eyelid were epilated and examined. The study subjects were followed-up once a week for four visits.

RESULTS

There was a difference in the mite count between the subgroups taking ivermectin and combined therapy during all follow-up visits. At the last visit, in the combined therapy subgroup, 1.7% of patients showed no clinical improvement, 26.7% showed a marked clinical improvement, and 71.6% showed complete remission. In those on the ivermectin regimen, 27 patients had a mite count >5 mites/cm², 21.7% showed no clinical improvement, 33.3% showed a marked improvement, and 45% showed complete remission.

CONCLUSIONS

Combined therapy was superior in decreasing the D. folliculorum count in all groups and in reducing the mite count to the normal level in rosacea and in anterior blepharitis. On the other hand, the two regimens were comparable in reducing the mite count to the normal level in acne and peri-oral dermatitis lesions.

Authors+Show Affiliations

Medical Parasitology Department, Faculty of Medicine, Mansoura University, Gomhoria Street, Mansoura City, Egypt. dr_doaasalem@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23294870

Citation

Salem, Doaa Abdel-Badie, et al. "Evaluation of the Efficacy of Oral Ivermectin in Comparison With Ivermectin-metronidazole Combined Therapy in the Treatment of Ocular and Skin Lesions of Demodex Folliculorum." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 17, no. 5, 2013, pp. e343-7.
Salem DA, El-Shazly A, Nabih N, et al. Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. Int J Infect Dis. 2013;17(5):e343-7.
Salem, D. A., El-Shazly, A., Nabih, N., El-Bayoumy, Y., & Saleh, S. (2013). Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 17(5), e343-7. https://doi.org/10.1016/j.ijid.2012.11.022
Salem DA, et al. Evaluation of the Efficacy of Oral Ivermectin in Comparison With Ivermectin-metronidazole Combined Therapy in the Treatment of Ocular and Skin Lesions of Demodex Folliculorum. Int J Infect Dis. 2013;17(5):e343-7. PubMed PMID: 23294870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. AU - Salem,Doaa Abdel-Badie, AU - El-Shazly,Atef, AU - Nabih,Nairmen, AU - El-Bayoumy,Youssef, AU - Saleh,Sameh, Y1 - 2013/01/05/ PY - 2012/04/16/received PY - 2012/11/09/revised PY - 2012/11/18/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/10/22/medline SP - e343 EP - 7 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 17 IS - 5 N2 - OBJECTIVE: To evaluate the efficacy of ivermectin and combined ivermectin-metronidazole therapy in the treatment of ocular and skin lesions of Demodex folliculorum. METHODS: One hundred twenty patients with skin lesions and anterior blepharitis, whose infestation was treatment-resistant and who had a Demodex count >5 mites/cm² for skin lesions or ≥ 3 mites at the root of each eyelash, were recruited. The treatment regimens were ivermectin and ivermectin-metronidazole combined therapy. We enrolled 15 patients from each of four groups for each treatment regimen. Demodex was detected by standardized skin surface biopsy for skin lesions. Three eyelashes from each affected lower eyelid were epilated and examined. The study subjects were followed-up once a week for four visits. RESULTS: There was a difference in the mite count between the subgroups taking ivermectin and combined therapy during all follow-up visits. At the last visit, in the combined therapy subgroup, 1.7% of patients showed no clinical improvement, 26.7% showed a marked clinical improvement, and 71.6% showed complete remission. In those on the ivermectin regimen, 27 patients had a mite count >5 mites/cm², 21.7% showed no clinical improvement, 33.3% showed a marked improvement, and 45% showed complete remission. CONCLUSIONS: Combined therapy was superior in decreasing the D. folliculorum count in all groups and in reducing the mite count to the normal level in rosacea and in anterior blepharitis. On the other hand, the two regimens were comparable in reducing the mite count to the normal level in acne and peri-oral dermatitis lesions. SN - 1878-3511 UR - https://brain.unboundmedicine.com/medline/citation/23294870/Evaluation_of_the_efficacy_of_oral_ivermectin_in_comparison_with_ivermectin_metronidazole_combined_therapy_in_the_treatment_of_ocular_and_skin_lesions_of_Demodex_folliculorum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(12)01315-X DB - PRIME DP - Unbound Medicine ER -