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Clinical treatment of ocular Demodex folliculorum by systemic ivermectin.
Am J Ophthalmol. 2011 Jun; 151(6):1030-1034.e1.AJ

Abstract

PURPOSE

To report clinical outcomes of the treatment of ocular Demodex folliculorum with oral ivermectin.

DESIGN

Noncomparative, interventional case series.

METHODS

Setting. Institutional. Study Population. Twenty-four eyes of 12 patients (3 male and 9 female; mean age ± standard deviation, 50.4 ± 21.0 years) with refractory posterior blepharitis with the presence of D. folliculorum in lash samples were enrolled in this study. Intervention. Patients were instructed to take 1 dose of oral ivermectin (200 μg/kg). All patients were instructed to repeat the treatment after 7 days. Main outcome measures. Tear meniscus height, Schirmer I test results, noninvasive tear film break-up time (BUT), quantification of the absolute number of D. folliculorum found in the lashes, and corneal fluorescein and rose bengal staining scores were obtained from all patients 1 day before and 28 days after treatment.

RESULTS

Statistical improvement was observed in the absolute number of D. folliculorum found in the lashes after the treatment with oral ivermectin. Average values of Schirmer I test results and tear film break-up time improved statistically after the treatment of oral ivermectin. No statistical improvement was observed in average lacrimal meniscus height or value of corneal fluorescein and rose bengal staining after treatment with oral ivermectin.

CONCLUSIONS

Ivermectin successfully reduced the number of D. folliculorum found in the lashes of patients with refractory blepharitis. Oral ivermectin may be very useful as a complement in the treatment of D. folliculorum infestation with ocular manifestation, especially in cases of unsuccessful treatment related to patient compliance.

Authors+Show Affiliations

Department of Ophthalmology, School of Medicine, Hospital das Clínicas of University of São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21334593

Citation

Holzchuh, Flávio Gaieta, et al. "Clinical Treatment of Ocular Demodex Folliculorum By Systemic Ivermectin." American Journal of Ophthalmology, vol. 151, no. 6, 2011, pp. 1030-1034.e1.
Holzchuh FG, Hida RY, Moscovici BK, et al. Clinical treatment of ocular Demodex folliculorum by systemic ivermectin. Am J Ophthalmol. 2011;151(6):1030-1034.e1.
Holzchuh, F. G., Hida, R. Y., Moscovici, B. K., Villa Albers, M. B., Santo, R. M., Kara-José, N., & Holzchuh, R. (2011). Clinical treatment of ocular Demodex folliculorum by systemic ivermectin. American Journal of Ophthalmology, 151(6), 1030-e1. https://doi.org/10.1016/j.ajo.2010.11.024
Holzchuh FG, et al. Clinical Treatment of Ocular Demodex Folliculorum By Systemic Ivermectin. Am J Ophthalmol. 2011;151(6):1030-1034.e1. PubMed PMID: 21334593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical treatment of ocular Demodex folliculorum by systemic ivermectin. AU - Holzchuh,Flávio Gaieta, AU - Hida,Richard Yudi, AU - Moscovici,Bernardo Kaplan, AU - Villa Albers,Marcos Bottene, AU - Santo,Ruth Miyuki, AU - Kara-José,Newton, AU - Holzchuh,Ricardo, Y1 - 2011/02/19/ PY - 2010/08/17/received PY - 2010/11/21/revised PY - 2010/11/22/accepted PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/7/28/medline SP - 1030 EP - 1034.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 151 IS - 6 N2 - PURPOSE: To report clinical outcomes of the treatment of ocular Demodex folliculorum with oral ivermectin. DESIGN: Noncomparative, interventional case series. METHODS: Setting. Institutional. Study Population. Twenty-four eyes of 12 patients (3 male and 9 female; mean age ± standard deviation, 50.4 ± 21.0 years) with refractory posterior blepharitis with the presence of D. folliculorum in lash samples were enrolled in this study. Intervention. Patients were instructed to take 1 dose of oral ivermectin (200 μg/kg). All patients were instructed to repeat the treatment after 7 days. Main outcome measures. Tear meniscus height, Schirmer I test results, noninvasive tear film break-up time (BUT), quantification of the absolute number of D. folliculorum found in the lashes, and corneal fluorescein and rose bengal staining scores were obtained from all patients 1 day before and 28 days after treatment. RESULTS: Statistical improvement was observed in the absolute number of D. folliculorum found in the lashes after the treatment with oral ivermectin. Average values of Schirmer I test results and tear film break-up time improved statistically after the treatment of oral ivermectin. No statistical improvement was observed in average lacrimal meniscus height or value of corneal fluorescein and rose bengal staining after treatment with oral ivermectin. CONCLUSIONS: Ivermectin successfully reduced the number of D. folliculorum found in the lashes of patients with refractory blepharitis. Oral ivermectin may be very useful as a complement in the treatment of D. folliculorum infestation with ocular manifestation, especially in cases of unsuccessful treatment related to patient compliance. SN - 1879-1891 UR - https://brain.unboundmedicine.com/medline/citation/21334593/Clinical_treatment_of_ocular_Demodex_folliculorum_by_systemic_ivermectin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(10)00952-9 DB - PRIME DP - Unbound Medicine ER -