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Efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites.
Arzneimittelforschung. 2004; 54(7):416-21.A

Abstract

Ivermectin (CAS 70288-86-7) is a potent antiparasitic drug. However, studies have not been published evaluating the efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites. Here the results of an open trial on the efficacy of ivermectin in a heavily poly-parasitized population in northeast Brazil are presented. Two hundred and fifty-one patients were enrolled. Two doses of ivermectin (200 microg/kg) were given at an interval of 10 days. The cure rates for intestinal helminthiases were: 100% for strongyloidiasis and enterobiasis, 99% for ascariasis, 84% for trichuriasis, 68% for hookworm disease, and 50% for hymenolepiasis. Cure rates for ectoparasitoses were: 100% for cutaneous larva migrans, 99% for pediculosis, 88% for scabies and 64% for tungiasis. The results show that two doses of ivermectin are highly efficacious for most intestinal helminths and ectoparasites simultaneously present in an impoverished population. The drug seems to be particularly useful when polyparasitism is expected to occur or when public health measures aim to reduce both intestinal helminthiases and parasitic skin diseases by mass chemotherapy.

Authors+Show Affiliations

Department of Community Health, Federal University of Ceará State, Fortaleza CE Brazil. samsa@mcanet.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15344847

Citation

Heukelbach, Jörg, et al. "Efficacy of Ivermectin in a Patient Population Concomitantly Infected With Intestinal Helminths and Ectoparasites." Arzneimittel-Forschung, vol. 54, no. 7, 2004, pp. 416-21.
Heukelbach J, Wilcke T, Winter B, et al. Efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites. Arzneimittelforschung. 2004;54(7):416-21.
Heukelbach, J., Wilcke, T., Winter, B., Sales de Oliveira, F. A., Sabóia Moura, R. C., Harms, G., Liesenfeld, O., & Feldmeier, H. (2004). Efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites. Arzneimittel-Forschung, 54(7), 416-21.
Heukelbach J, et al. Efficacy of Ivermectin in a Patient Population Concomitantly Infected With Intestinal Helminths and Ectoparasites. Arzneimittelforschung. 2004;54(7):416-21. PubMed PMID: 15344847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites. AU - Heukelbach,Jörg, AU - Wilcke,Thomas, AU - Winter,Benedikt, AU - Sales de Oliveira,Fabíola Araújo, AU - Sabóia Moura,Rômulo César, AU - Harms,Gundel, AU - Liesenfeld,Oliver, AU - Feldmeier,Hermann, PY - 2004/9/4/pubmed PY - 2004/9/24/medline PY - 2004/9/4/entrez SP - 416 EP - 21 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 54 IS - 7 N2 - Ivermectin (CAS 70288-86-7) is a potent antiparasitic drug. However, studies have not been published evaluating the efficacy of ivermectin in a patient population concomitantly infected with intestinal helminths and ectoparasites. Here the results of an open trial on the efficacy of ivermectin in a heavily poly-parasitized population in northeast Brazil are presented. Two hundred and fifty-one patients were enrolled. Two doses of ivermectin (200 microg/kg) were given at an interval of 10 days. The cure rates for intestinal helminthiases were: 100% for strongyloidiasis and enterobiasis, 99% for ascariasis, 84% for trichuriasis, 68% for hookworm disease, and 50% for hymenolepiasis. Cure rates for ectoparasitoses were: 100% for cutaneous larva migrans, 99% for pediculosis, 88% for scabies and 64% for tungiasis. The results show that two doses of ivermectin are highly efficacious for most intestinal helminths and ectoparasites simultaneously present in an impoverished population. The drug seems to be particularly useful when polyparasitism is expected to occur or when public health measures aim to reduce both intestinal helminthiases and parasitic skin diseases by mass chemotherapy. SN - 0004-4172 UR - https://brain.unboundmedicine.com/medline/citation/15344847/Efficacy_of_ivermectin_in_a_patient_population_concomitantly_infected_with_intestinal_helminths_and_ectoparasites_ DB - PRIME DP - Unbound Medicine ER -